货号 :

分子式 :

C42H52BrClN2O4

纯度 :

99%+

分子量 :

764.23

存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 20 mg/mL(26.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

MDL号 :

N/A

描述

Photodynamic therapy (PDT) is a burgeoning method for cancer therapy attribute to low side effect, minimal invasiveness, and high space-time selectivity. IR-808 is a PDT photosensitizer with cancer-targeting ability and near-infrared (NIR) sensitivity. When irradiated by tissue-penetrable 808 nm light, the IR-808 greatly absorbs 808 nm photons and then emit a broadband peak which overlaps perfectly with the absorption of Nd3+ and Yb3+. The Nd3+/Yb3+ incorporated shell synergistically captures the emitted NIR photons to illuminate NaGdF4:Yb,Er zone and then radiate ultra-bright green and red emissions. The visible emissions simultaneously activate the dual-photosensitizer to produce a large amount of ROS and, importantly, low heating effects. IR-808 could be internalized selectively by malignant cells of samples, and these malignant cells could be easily distinguished from normal cells under a fluorescence microscope. The positive rates between cytological analysis and the IR-808 staining method were 86% (24/28) and 79% (22/28), respectively. An excellent concordance level (Kappa = 0.752, P < 0.001) was observed between the two methods

质量

体积

浓度

1mg

5mg

10mg

1 mM

1.31ml

6.54ml

13.09ml

5 mM

0.26ml

1.31ml

2.62ml

10 mM

0.13ml

0.65ml

1.31ml